DTI vs Hardi

Imeka is your best ally when it comes to getting the most out of the science of imaging. Our fiber tractography technique, based on HARDI (high angular resolution diffusion imaging) instead of DTI (diffusion tensor imaging), makes a huge difference in the extent of what you can do with tractography and to the regions of white matter you can target via fiber bundling.

Fiber tractography is an extension of the basic processing of diffusion MRI. Once you know the directions water diffuses inside voxels, you can connect the dots to visualize the connections as a whole in the brain’s white matter.

What it means for neurosurgeons:

Tractography at Imeka is the most reproducible, fast and affordable way to get high quality visual representation of pathways that should and should not be cut during surgery.

What it means for pharmaceutical research:

Tractography at Imeka is used to expose regions of interest (via bundling) and microstructural elements within these regions. Although it shouldn’t be used as  a way to quantify connectivity between specific grey matter areas, it lets us see specific regions instead of the brain as a whole.

We pride ourselves on honing our skill to the point where we know its exact limitations.

Therefore, we know tractography is not robust enough to extract statistics and quantify connectivity properly for research. Maxime Descoteaux, our founder and CSO, has been part of a consortium that published a Nature Communication paper specifically on that matter.

A bit of back story

For the last 15 years, Maxime has been at the helm of the SCIL (Sherbrooke connectivity imaging lab). The lab is known for its integrated approach to diffusion MRI, therefore tractography is a central part of what it does. Imeka being an extension of the lab, its approach is embedded in our company.